At present,,there is a gap on preparation technique of osmotic pump controlled-release tablets between domestic and oversea for laser drilling equipmenmt, composition of semi-permeable membrane, the optimization of coating process and drug releaseing incompletely.
We modified technology are created to using lubrication layer to push against the layer containing the drug to gradually and completely release,the release can reach 100%.The modified technology are designed to apply in all double-layer osmotic pump controlled release formulations and has been commercialized.
Advantages of the technology:
1.Optimize the prescription of semi-permeable membrane and coating process
2.Easily identify drug layer for transparent semi-permeable membrane
The technology was used to develop Nifedipine Controlled Release Tablet, Mesylate Doxazosin Controlled Release Tablet, Glipizide Controlled Release Tablet,etc.



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